Lamy Olivier, Krieg Marc-Antoine, Burckhardt Peter
Service de médecine A, BH10-614, CHUV, 1011 Lausanne.
Rev Med Suisse Romande. 2002 Aug;122(8):383-7.
The aim of this review is to better identify for which women with osteoporosis the treatment is efficient, without taking into account the bone mineral density only. The age, previous fractures, the severity of vertebral deformity identify women at high risk for subsequent fracture. The development of assessment tools for predicting fracture risk, the use of the NNT (number needed to treat), and economical analyses are particularly helpful. The number of patients needed to treat to prevent one patient having the target event expresses the magnitude of a treatment effect in a clinically useful way. Economical analyses take into account the health care resources needed to get these benefits. We analysed the NNT and the cost of the treatments which significantly reduced the risk of fracture.
本综述的目的是更好地确定哪些骨质疏松症女性患者的治疗是有效的,而不仅仅考虑骨密度。年龄、既往骨折史、椎体畸形的严重程度可识别出后续骨折风险高的女性。开发预测骨折风险的评估工具、使用治疗所需人数(NNT)以及进行经济分析特别有帮助。预防一名患者发生目标事件所需治疗的患者数量以一种临床有用的方式表达了治疗效果的大小。经济分析考虑了获得这些益处所需的医疗资源。我们分析了能显著降低骨折风险的治疗方法的NNT和成本。