Jones C, Wuthier P, Puck T T
Somatic Cell Genet. 1975 Jul;1(3):235-46. doi: 10.1007/BF01538448.
The AL antigen present on the surface of various human somatic cells, and on those hybrids of human and Chinese hamster ovary cells which have retained human chromosome number 11, has been resolved into at least two separate antigenic activities, a1 and a2. Specific antisera active against each antigen separately have been prepared. By treatment of the original AL+ hybrid with mutagenic agents and selection in particular antisera, stable clones are preparable whose phenotypic behavior corresponds to the antigenic compositions a1+ a2-, a1- a2+, and a1- a2-. The adsorption behavior of these variants for specific antisera is consistent with their phenotypic assignments.
存在于各种人类体细胞表面以及保留了人类11号染色体的人-中国仓鼠卵巢细胞杂种表面的AL抗原，已被解析为至少两种独立的抗原活性，即a1和a2。已制备出分别针对每种抗原具有活性的特异性抗血清。通过用诱变剂处理原始的AL+杂种并在特定抗血清中进行筛选，可制备出稳定的克隆，其表型行为与抗原组成a1+ a2-、a1- a2+和a1- a2-相对应。这些变体对特异性抗血清的吸附行为与其表型归属一致。
