Wang Daolong, Lemon William J, You Ming
Division of Human Cancer Genetics, The Ohio State University Comprehensive Cancer, 514 Medical Research Facility, 420 West 12th Avenue, Columbus, Ohio, OH 43210, USA.
Oncogene. 2002 Oct 3;21(44):6858-65. doi: 10.1038/sj.onc.1205886.
Linkage disequilibrium (LD) has been used to map chromosomal regions regulating quantitative traits, also called quantitative trait loci (QTLs). With the increasing number of available mouse polymorphic genetic markers, LD can be estimated for the purpose of fine-mapping a given QTL or in the identification of novel QTLs. A whole-genome LD analysis was conducted for mapping mouse lung tumor susceptibility QTLs in 25 strains of mice with known susceptibility to lung cancer using 5638 genetic markers. A total of 63 markers were found to be significantly associated with lung tumor susceptibility, many of which were novel QTLs. This study demonstrates the feasibility of using LD to map QTLs on a whole genome level. Further characterization of the newly identified lung tumor susceptibility QTLs may lead to the identification of genes whose human homologue may predispose some individuals to lung cancer.
连锁不平衡（LD）已被用于定位调控数量性状的染色体区域，这些区域也被称为数量性状基因座（QTL）。随着可用小鼠多态性遗传标记数量的增加，LD可用于精细定位给定的QTL或鉴定新的QTL。利用5638个遗传标记，对25种已知肺癌易感性的小鼠品系进行了全基因组LD分析，以定位小鼠肺癌易感性QTL。共发现63个标记与肺癌易感性显著相关，其中许多是新的QTL。这项研究证明了在全基因组水平上使用LD定位QTL的可行性。对新鉴定的肺癌易感性QTL的进一步表征可能会导致鉴定出其人类同源基因可能使某些个体易患肺癌的基因。
Zotero 插件