Lohse Nicolai, Obel Niels
Infektionsmedicinsk afdeling Q, Skejby Sygehus, Braendstrupgårdsvej 100, DK-8240 Arhus N.
Ugeskr Laeger. 2002 Sep 2;164(36):4190-2.
Herpes simplex virus type 1 (HSV-1) is well-known as a cause of orolabial ulcers, whereas HSV-2 predominantly causes genital infections. Furthermore, HSV can lead to severe infections in the central nervous system (CNS). In adults, HSV encephalitis is predominantly caused by HSV-1, whereas HSV-2 mainly leads to aseptic meningitis, the symptoms of which are seen with or without concurrent genital ulcers. We describe four cases of HSV-2-associated aseptic meningitis. One of the patients had a primary HSV infection, and another had recurrent aseptic meningitis. All the patients recovered without neurological sequelae.
单纯疱疹病毒1型(HSV-1)是引起口腔唇溃疡的常见病因,而HSV-2主要引起生殖器感染。此外,HSV可导致中枢神经系统(CNS)的严重感染。在成年人中,HSV脑炎主要由HSV-1引起,而HSV-2主要导致无菌性脑膜炎,无论有无并发生殖器溃疡均可出现其症状。我们描述了4例与HSV-2相关的无菌性脑膜炎病例。其中1例患者为原发性HSV感染,另1例患有复发性无菌性脑膜炎。所有患者均康复,未遗留神经后遗症。