内侧颞叶癫痫中外侧海马NAA减少。
Reduced extrahippocampal NAA in mesial temporal lobe epilepsy.
作者信息
Mueller Susanne G, Suhy Joyce, Laxer Kenneth D, Flenniken Derek L, Axelrad Jana, Capizzano Andres A, Weiner Michael W
机构信息
Department of Veterans Affairs (DVA) Medical Center, Magnetic Resonance Spectroscopy Unit, University of California San Francisco, California 94143-0138, USA.
出版信息
Epilepsia. 2002 Oct;43(10):1210-6. doi: 10.1046/j.1528-1157.2002.10802.x.
PURPOSE
Structural and metabolic abnormalities in the hippocampal region in medial temporal lobe epilepsy (mTLE) are well described; less is known about extrahippocampal changes. This study was designed to characterize extrahippocampal metabolic abnormalities in mTLE with magnetic resonance spectroscopy in combination with tissue segmentation and volumetry of gray and white matter.
METHODS
Multislice magnetic resonance spectroscopic imaging (1H-MRSI) in combination with tissue segmentation was performed on 16 patients with mTLE and 12 age-matched healthy volunteers. The data were analyzed by using a regression-analysis model that estimated the metabolite concentrations in 100% cortical gray and 100% white matter in the frontal lobe and nonfrontal brain. The segmented image was used to calculate the fraction of gray and white matter in these regions.
RESULTS
mTLE had significantly lower N-acetyl aspartate (NAA) in ipsi- and contralateral frontal gray (p = 0.03) and in ipsi- and contralateral nonfrontal white matter (p = 0.008) compared with controls. Although there were no associated volumetric deficits in frontal gray and white matter, ipsilateral nonfrontal gray matter (p = 0.003) was significantly smaller than that in controls.
CONCLUSIONS
mTLE is associated with extrahippocampal metabolic abnormalities and volumetric deficits, but these do not necessarily affect the same regions.
目的
内侧颞叶癫痫（mTLE）患者海马区的结构和代谢异常已得到充分描述；而关于海马外变化的了解较少。本研究旨在通过磁共振波谱结合灰质和白质的组织分割及体积测量来描述mTLE患者海马外的代谢异常。
方法
对16例mTLE患者和12名年龄匹配的健康志愿者进行了多层磁共振波谱成像（1H-MRSI）结合组织分割。使用回归分析模型分析数据，该模型估计额叶和非额叶脑区100%皮质灰质和100%白质中的代谢物浓度。分割后的图像用于计算这些区域中灰质和白质的比例。
结果
与对照组相比，mTLE患者同侧和对侧额叶灰质（p = 0.03）以及同侧和对侧非额叶白质（p = 0.008）中的N-乙酰天门冬氨酸（NAA）显著降低。虽然额叶灰质和白质没有相关的体积缺失，但同侧非额叶灰质（p = 0.003）明显小于对照组。
结论
mTLE与海马外代谢异常和体积缺失有关，但这些不一定影响相同的区域。
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