作用于肾素-血管紧张素系统的抗高血压药物，重点是AT(1)拮抗剂。

Antihypertensive drugs that act on Renin-Angiotensin System with emphasis in AT(1) antagonists.

作者信息

Mavromoustakos T, Apostolopoulos V, Matsoukas J

机构信息

Institute of Organic and Pharmaceutical Chemistry, National Hellenic Research Foundation, Athens, Greece.

出版信息

Mini Rev Med Chem. 2001 Jul;1(2):207-17. doi: 10.2174/1389557013407115.

DOI:10.2174/1389557013407115

PMID:12369985

Abstract

Angiotensin II, the primary active hormone in the Renin-Angiotensin System is a major vasoconstrictor implicated in the cause of hypertension. Research efforts have focused in the treatment of disease by blocking its release and more recently by competing its action on AT(1) receptors. This approach generated in the pharmaceutical market, losartan, and other derivatives. To better understand the stereoelectronic requirements that lead to the molecular basis of hypertension the stereochemical features of angiotensin II and its antagonists are studied.

摘要

血管紧张素II是肾素-血管紧张素系统中的主要活性激素，是一种与高血压病因相关的主要血管收缩剂。研究工作主要集中在通过阻断其释放以及最近通过竞争其对AT(1)受体的作用来治疗该疾病。这种方法催生了药物市场上的氯沙坦及其他衍生物。为了更好地理解导致高血压分子基础的立体电子要求，人们对血管紧张素II及其拮抗剂的立体化学特征进行了研究。