异源三聚体G蛋白控制着多种跨膜信号传导途径，这是药物研发的基础。

Heterotrimeric G proteins control diverse pathways of transmembrane signaling, a base for drug discovery.

作者信息

Landry Y, Gies J P

机构信息

Laboratoire de Neuroimmunopharmacologie, INSERM U425, Faculté de Pharmacie, Université Louis Pasteur - Strasbourg 1, BP24, 67401 Illkirch Cedex, France.

出版信息

Mini Rev Med Chem. 2002 Aug;2(4):361-72. doi: 10.2174/1389557023405945.

DOI:10.2174/1389557023405945

PMID:12370057

Abstract

Heptahelical receptors are coupled to heterotrimeric GTP-binding proteins (G proteins) which transduce most signals through their alpha and betagamma subunits to effectors including adenylylcyclases, ion channels, phospholipases Cbeta, and phosphoinositide 3-kinases. The diversity of G proteins, their effectors and regulators (RGS proteins), supports the interest of these protein families as potential drug targets.

摘要

七螺旋受体与异源三聚体GTP结合蛋白（G蛋白）偶联，这些G蛋白通过其α和βγ亚基将大多数信号转导至效应器，包括腺苷酸环化酶、离子通道、磷脂酶Cβ和磷酸肌醇3激酶。G蛋白、其效应器和调节剂（RGS蛋白）的多样性，使得这些蛋白家族成为潜在药物靶点备受关注。