Hervé J C
Laboratoire de Physiologie Cellulaire, UMR CNRS-Université de Poitiers 6558, 40 avenue du R. Pineau, France.
Mini Rev Med Chem. 2002 Aug;2(4):411-7. doi: 10.2174/1389557023405981.
Steroid hormones may possess two distinct actions, a delayed genomic influence and the rapid nongenomic effects, which may act in concert. Nongenomic effect may be mediated by putative membrane receptors or due to allosteric interactions of steroids with membrane proteins (e.g. ionic channels), inducing rapid changes in protein/receptor/channel activation or inhibition.
类固醇激素可能具有两种不同的作用,一种是延迟的基因组影响,另一种是快速的非基因组效应,这两种效应可能协同发挥作用。非基因组效应可能由假定的膜受体介导,或者是由于类固醇与膜蛋白(如离子通道)的变构相互作用,从而引起蛋白质/受体/通道激活或抑制的快速变化。