Clandinin Thomas R, Zipursky S Lawrence
Department of Biological Chemistry, Howard Hughes Medical Institute, University of California, School of Medicine, Los Angeles, CA 90095, USA.
Neuron. 2002 Aug 29;35(5):827-41. doi: 10.1016/s0896-6273(02)00876-0.
Understanding the molecular mechanisms that regulate formation of precise patterns of neuronal connections within the central nervous system remains a challenging problem in neurobiology. Genetic studies in worms and flies and molecular studies in vertebrate systems have led to an increasingly sophisticated understanding of how growth cones navigate toward their targets and form topographic maps. Considerably less is known about how growth cones recognize their cellular targets and form synapses with them. Here, we review connection formation in the fly visual system, the methodological approaches used to study it, and recent progress in uncovering the molecular basis of connection specificity.
了解调节中枢神经系统内精确神经元连接模式形成的分子机制，仍然是神经生物学中一个具有挑战性的问题。对蠕虫和果蝇的遗传学研究以及对脊椎动物系统的分子研究，使人们对生长锥如何向其靶标导航并形成地形图有了越来越深入的理解。关于生长锥如何识别其细胞靶标并与之形成突触，人们所知甚少。在这里，我们回顾果蝇视觉系统中的连接形成、用于研究它的方法以及在揭示连接特异性分子基础方面的最新进展。
