[地塞米松对硬膜外吗啡相关恶心和呕吐的影响]
[Effects of dexamethasone on epidural morphine-related nausea and vomiting].
作者信息
Wu You-Wu, Xu Jian-She, Chen Zhong-Qing, Gu Miao-Ning, Wang Yu-Zheng
机构信息
Department of Anesthesiology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Aug;22(8):758-9.
OBJECTIVE
To observe the effect of intravenous dexamethasone injections in preventing nausea and vomiting resulted from epidural morphine for post-operation pain relief.
METHODS
Eighty-four adult patients (ASA class I to II ) requiring epidural anesthesia for low abdominal surgical procedures were randomly divided into 2 groups, of which Group 1 (n=42) received intravenous dexamethasone injections at 10 mg and Group 2 (n=42) intravenous injection of 2 ml normal saline before administration of 2 mg epidural morphine for post-operation pain relief. The incidence of nausea and vomiting were recorded within 24 h after surgery.
RESULTS
The incidence of nausea and vomiting were 12% and 7% in Group 1, while 31% and 21% in Group 2 respectively, showing significant difference between the 2 groups (P<0.05). The total incidence of nausea and vomiting were also significantly different (19% vs 52%, P<0.01).
CONCLUSION
Intravenous dexamethasone injections at 10 mg can significantly decrease the incidence of epidural morphine-related nausea and vomiting.
目的
观察静脉注射地塞米松对预防硬膜外吗啡用于术后镇痛所致恶心呕吐的效果。
方法
84例拟行下腹部手术需硬膜外麻醉的成年患者（ASA分级Ⅰ～Ⅱ级）随机分为2组，每组42例。第1组于硬膜外注射2mg吗啡用于术后镇痛前静脉注射地塞米松10mg，第2组静脉注射2ml生理盐水。记录术后24小时内恶心呕吐的发生率。
结果
第1组恶心和呕吐的发生率分别为12%和7%，第2组分别为31%和21%，两组间差异有统计学意义（P<0.05）。恶心呕吐的总发生率也有显著差异（19%对52%，P<0.01）。
结论
静脉注射10mg地塞米松可显著降低硬膜外吗啡相关恶心呕吐的发生率。
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