Wagner E F
Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria.
Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii40-2. doi: 10.1136/ard.61.suppl_2.ii40.
Genetically modified mice and cells have provided important insights into the biological functions of the dimeric transcription factor complex AP1, in particular into its role in skeletal development. Data obtained from knockout mice revealed that some components, such as c-Fos are key regulators of bone cell differentiation, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic and/or postnatal development. Apart from identifying the specific roles of AP1 proteins in developmental processes, researchers are beginning to obtain a better molecular understanding of their cell-context dependent functions, their downstream target genes and how they regulate bone cell proliferation, differentiation, and apoptosis.
转基因小鼠和细胞为深入了解二聚体转录因子复合物AP1的生物学功能提供了重要见解，特别是其在骨骼发育中的作用。从基因敲除小鼠获得的数据表明，一些成分，如c-Fos是骨细胞分化的关键调节因子，而其他成分，如c-Jun、JunB和Fra-1在胚胎和/或出生后发育中至关重要。除了确定AP1蛋白在发育过程中的特定作用外，研究人员还开始对其细胞背景依赖性功能、下游靶基因以及它们如何调节骨细胞增殖、分化和凋亡有了更好的分子理解。
