AP1（Fos/Jun）在骨骼发育中的功能。
Functions of AP1 (Fos/Jun) in bone development.
作者信息
Wagner E F
机构信息
Research Institute of Molecular Pathology (IMP), Dr Bohr-Gasse 7, A-1030 Vienna, Austria.
出版信息
Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii40-2. doi: 10.1136/ard.61.suppl_2.ii40.
Abstract
Genetically modified mice and cells have provided important insights into the biological functions of the dimeric transcription factor complex AP1, in particular into its role in skeletal development. Data obtained from knockout mice revealed that some components, such as c-Fos are key regulators of bone cell differentiation, whereas others, like c-Jun, JunB and Fra-1 are essential in embryonic and/or postnatal development. Apart from identifying the specific roles of AP1 proteins in developmental processes, researchers are beginning to obtain a better molecular understanding of their cell-context dependent functions, their downstream target genes and how they regulate bone cell proliferation, differentiation, and apoptosis.
摘要
转基因小鼠和细胞为深入了解二聚体转录因子复合物AP1的生物学功能提供了重要见解，特别是其在骨骼发育中的作用。从基因敲除小鼠获得的数据表明，一些成分，如c-Fos是骨细胞分化的关键调节因子，而其他成分，如c-Jun、JunB和Fra-1在胚胎和/或出生后发育中至关重要。除了确定AP1蛋白在发育过程中的特定作用外，研究人员还开始对其细胞背景依赖性功能、下游靶基因以及它们如何调节骨细胞增殖、分化和凋亡有了更好的分子理解。
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本文引用的文献
1
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Nat Cell Biol. 2002 May;4(5):E131-6. doi: 10.1038/ncb0502-e131.
2
Reaching a genetic and molecular understanding of skeletal development.达成对骨骼发育的基因和分子层面的理解。
Dev Cell. 2002 Apr;2(4):389-406. doi: 10.1016/s1534-5807(02)00157-0.
3
RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta.核因子κB受体活化因子配体（RANKL）通过依赖于c-Fos的干扰素-β诱导来维持骨稳态。
Nature. 2002 Apr 18;416(6882):744-9. doi: 10.1038/416744a.
4
Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver.肝脏中缺乏c-jun的小鼠出生后肝细胞增殖和肝脏再生受损。
EMBO J. 2002 Apr 2;21(7):1782-90. doi: 10.1093/emboj/21.7.1782.
5
Genetic control of skeletal development.骨骼发育的遗传控制
Curr Opin Genet Dev. 2001 Oct;11(5):527-32. doi: 10.1016/s0959-437x(00)00228-8.
6
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7
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8
Placental vascularisation requires the AP-1 component fra1.胎盘血管生成需要AP-1成分Fra1。
Development. 2000 Nov;127(22):4937-48. doi: 10.1242/dev.127.22.4937.
9
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