Understanding the biosynthetic pathways involved in cellular transport is an important issue in cell biology. More than a hundred years after the discovery of the Golgi apparatus, we still do not understand the regulation of vesicular transport to, within and from the Golgi apparatus. Recently, however, it has become clear that cargo might not simply be a passive passenger, and that ADP-ribosylation factor (ARF) GAPs are not only GTPase-activating proteins for ARF, but might play crucial roles in regulating coat protein complex I vesicle formation.