超顺磁性氧化铁（菲立磁）增强磁共振成像在局灶性肝病变诊断中的应用
Superparamagnetic iron oxide (Feridex)-enhanced MRI in diagnosis of focal hepatic lesions.
作者信息
Wen Ge, Zhang Xue-Lin, Chang Ren-Min, Xia Qiong, Cang Peng, Zhang Ying
机构信息
Medical Imaging Center, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 May;22(5):451-2.
OBJECTIVE
To evaluate the diagnostic value of superparamagnetic iron oxide (SPIO)-enhanced magnetic resonance imaging (MRI) for hepatic focal solid lesions.
METHODS
SPIO (Feridex)-enhanced MRI examination was performed in 28 cases of hepatic space-occupying lesions defined by CT or MRI or other methods. In post-contrast enhanced examination, the signal intensity and contrast-to-noise ratio (CNR) were measured in lesions and normal hepatic parenchyma in T2-weighted images (T2WI) and were compared with those in pre-contrast enhanced MRI. The number and morphology of the lesions were visualized for qualitative diagnostic analysis.
RESULTS
In Feridex-enhanced MRI, the signal intensity of normal hepatic parenchyma was decreased while the CNR between lesions and normal liver tissues significantly improved in comparison with that in pre-contrast enhanced examination.
CONCLUSION
Feridex-enhanced T2WI examination significantly improves detection of hepatic lesions and is valuable in diagnosing hepatic focal solid lesions.
目的
评估超顺磁性氧化铁（SPIO）增强磁共振成像（MRI）对肝脏局灶性实性病变的诊断价值。
方法
对28例经CT、MRI或其他方法确诊的肝脏占位性病变患者进行SPIO（菲立磁）增强MRI检查。在对比增强检查后，测量T2加权像（T2WI）上病变及正常肝实质的信号强度和对比噪声比（CNR），并与对比增强前的MRI进行比较。观察病变的数量和形态以进行定性诊断分析。
结果
在菲立磁增强MRI中，与对比增强前检查相比，正常肝实质信号强度降低，病变与正常肝组织之间的CNR显著提高。
结论
菲立磁增强T2WI检查显著提高了肝脏病变的检出率，对肝脏局灶性实性病变的诊断具有重要价值。
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