Sjakste Tatjana, Lauberte Lasma, Collan Yrjö, Savontaus Marja-Liisa, Bajare Alla, Scherrer Klaus, Sjakste Nikolajs
Institute of Biology of Latvian University, Miera Street 3, Salaspils LV2169, Latvia.
DNA Seq. 2002 Jun;13(3):139-43. doi: 10.1080/10425170290012655.
A TG dinucleotide repeat was identified in intron 6 of the human proteasome core particle PROS-27K (IOTA, PSMA6) gene. We present data on the length polymorphism of this repeat in 120 individuals from Latvia and 197 individuals from Finland. A combination of PCR and fluorescent gel electrophoresis was utilized to type the polymorphism. Twelve alleles were observed, varying in length from 10 to 23 TG repeats. Similar allele frequencies were observed in Latvian and Finnish subjects, with 17 and 20 repeats being the most frequent in both populations. We suggest that this TG dinucleotide repeat could be utilized as a prospective marker for genetic linkage and association studies of common diseases.
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