DeAmicis Tracy, Mofid Mona Z, Cohen Bernard, Nousari Hossein C
Johns Hopkins Medical Institutions and the Department of Dermatology, Johns Hopkins Hospital, Baltimore, MD, USA.
J Am Acad Dermatol. 2002 Nov;47(5 Suppl):S273-4. doi: 10.1067/mjd.2002.108586.
Urticarial vasculitis, a form of leukocytoclastic vasculitis involving the postcapillary venules, is classified as a type III hypersensitivity reaction and has been associated with connective tissue disease. The lesions resemble urticaria and typically persist for more than 24 hours. Urticarial vasculitis usually affects young women, and the diagnosis is confirmed at histologic examination. Patients with urticarial vasculitis can be divided into 2 types--those with normal complement levels and those with hypocomplementemic urticarial vasculitis (HUV). Patients with normocomplementemic urticarial vasculitis have a milder course than do patients with HUV, a condition that has a strong association with systemic lupus erythematosus. Angioedema, ocular inflammation, obstructive lung disease, and glomerulonephritis are commonly associated with HUV. We describe the case of a girl with systemic lupus erythematosus and HUV who also had pancreatitis, hypothyroidism, and elevated levels of antiphospholipid antibodies.
荨麻疹性血管炎是白细胞破碎性血管炎的一种形式，累及毛细血管后微静脉，被归类为III型超敏反应，且与结缔组织病有关。其皮损类似荨麻疹，通常持续超过24小时。荨麻疹性血管炎通常影响年轻女性，诊断需经组织学检查证实。荨麻疹性血管炎患者可分为两型——补体水平正常者和低补体血症性荨麻疹性血管炎（HUV）患者。补体正常的荨麻疹性血管炎患者病程比HUV患者轻，HUV与系统性红斑狼疮密切相关。血管性水肿、眼部炎症、阻塞性肺病和肾小球肾炎常与HUV相关。我们描述了一名患有系统性红斑狼疮和HUV的女孩的病例，她还患有胰腺炎、甲状腺功能减退和抗磷脂抗体水平升高。
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