Yokoyama Yukihiro, Schwacha Martin G, Samy T S Anantha, Bland Kirby I, Chaudry Irshad H
Center for Surgical Research and Department of Surgery, University of Alabama at Birmingham, 35294-0019, USA.
Immunol Res. 2002;26(1-3):63-76. doi: 10.1385/ir:26:1-3:063.
Previous studies have shown marked immunosuppression in males after trauma and hemorrhage. By contrast, immunosuppression was not evident in proestrous female animals. Further support for these findings came from studies demonstrating the immunosuppressive effects of male sex hormones and immunoenhancing effects of female sex hormones. In this regard, administration of 17beta-estradiol or prolactin to male animals after trauma and hemorrhage significantly improved immune function. Furthermore, castration or androgen receptor blockade with flutamide after trauma and hemorrhage in male mice showed similar beneficial effects. Thus, regulation of sex hormone synthesis or their receptor activity appears to be a useful therapeutic approach for patients to cope with the deleterious sequelae of severe trauma and hemorrhage.
先前的研究表明，雄性动物在创伤和出血后会出现明显的免疫抑制。相比之下，处于发情前期的雌性动物并未出现免疫抑制。这些发现得到了进一步支持，研究表明雄性激素具有免疫抑制作用，而雌性激素具有免疫增强作用。在这方面，创伤和出血后给雄性动物注射17β-雌二醇或催乳素可显著改善免疫功能。此外，雄性小鼠在创伤和出血后进行去势或用氟他胺阻断雄激素受体也显示出类似的有益效果。因此，调节性激素合成或其受体活性似乎是患者应对严重创伤和出血有害后遗症的一种有用治疗方法。
Zotero 插件