Curtis Lesley H, Phelps Charles E, McDermott Michael P, Rubin Haya R
Department of Community and Preventive Medicine, University of Rochester School of Medicine, Rochester, New York, USA.
Med Care. 2002 Nov;40(11):1090-100. doi: 10.1097/00005650-200211000-00010.
Risk stratification for comparison of outcomes after coronary artery bypass grafting (CABG) typically includes only clinical measures of risk. Patient-reported health status may be an important independent predictor of short-term health outcomes.
To determine whether patient-reported health status, as measured by the Physical and Mental Component Summary scores of the SF-36, predicts in-hospital mortality and prolonged length of stay after CABG, after controlling for other clinical predictors of those outcomes.
Prospective cohort study conducted from September 1993 to November 1995.
One thousand seven hundred seventy-eight adults who underwent isolated CABG for myocardial ischemia.
In-hospital mortality and prolonged length of stay (> 14 days).
There were 27 deaths and 223 patients with prolonged length of stay in the study sample. A 10-point decrease in the Physical Component Summary (PCS) score increased the odds of in-hospital mortality by 61% (OR, 1.61; 95% CI, 1.04-2.49), independent of established clinical risk factors. Similarly, a 10-point decrease in the PCS score increased the odds of prolonged length of stay by 33% (OR, 1.33; 95% CI, 1.13-1.57). A 10-point decrease in the Mental Component Summary score (MCS) decreased the odds of mortality by 36% (OR, 0.64; 95% CI, 0.43-0.95).
The PCS score is independently and significantly associated with in-hospital mortality and prolonged length of stay, after controlling for clinical risk factors. The MCS score is independently and significantly associated only with mortality, though the direction of the effect is unexpected. The result likely reflects a property of the scoring of the MCS and not a finding of clinical substance. Although caution must be taken when interpreting the summary scores, the SF-36 yields information not otherwise captured by clinical data and may be useful in risk stratification for in-hospital mortality and prolonged length of stay after CABG.
冠状动脉旁路移植术(CABG)后用于比较预后的风险分层通常仅包括临床风险指标。患者报告的健康状况可能是短期健康预后的重要独立预测因素。
在控制其他临床预后预测因素后,确定通过SF-36的生理和心理成分总结评分衡量的患者报告健康状况是否能预测CABG后的住院死亡率和延长住院时间。
1993年9月至1995年11月进行的前瞻性队列研究。
1778名因心肌缺血接受单纯CABG的成年人。
住院死亡率和延长住院时间(>14天)。
研究样本中有27例死亡和223例延长住院时间的患者。生理成分总结(PCS)评分降低10分,住院死亡率增加61%(OR,1.61;95%CI,1.04-2.49),独立于既定的临床风险因素。同样,PCS评分降低10分,延长住院时间的几率增加33%(OR,1.33;95%CI,1.13-1.57)。心理成分总结评分(MCS)降低10分,死亡率降低36%(OR,0.64;95%CI,0.43-0.95)。
在控制临床风险因素后,PCS评分与住院死亡率和延长住院时间独立且显著相关。MCS评分仅与死亡率独立且显著相关,尽管效应方向出乎意料。该结果可能反映了MCS评分的特性,而非临床实质发现。尽管在解释总结评分时必须谨慎,但SF-36产生了临床数据未捕捉到的信息,可能有助于CABG后住院死亡率和延长住院时间的风险分层。