骨形态发生蛋白在肾脏发育中的组织形式。

Organisation of bone morphogenetic proteins in renal development.

作者信息

Martinez Gemma, Bertram John F

机构信息

Institute for Molecular Bioscience, The University of Queensland, St. Lucia, Queensland, Australia.

出版信息

Nephron Exp Nephrol. 2003 Jan;93(1):e18-22. doi: 10.1159/000066649.

DOI:10.1159/000066649

PMID:12411745

Abstract

Bone morphogenetic proteins (BMPs) comprise the largest subfamily of the transforming growth factor-beta (TGF-beta) superfamily of secreted proteins. Evidence for the involvement of BMPs in metanephric development emerged recently when renal phenotypes were observed in BMP7 null mutant mice. Since then, several other BMPs, BMP receptor serine/threonine kinases and BMP signal transduction molecules (Smads) have been implicated in mammalian metanephric development. It appears that particular BMPs have pivotal roles in specific aspects of metanephric development. Current knowledge and evidence of specific roles of particular BMPs are presented in this review.

摘要

骨形态发生蛋白（BMPs）是分泌蛋白转化生长因子-β（TGF-β）超家族中最大的亚家族。当在BMP7基因敲除突变小鼠中观察到肾脏表型时，BMPs参与后肾发育的证据最近才出现。从那时起，其他几种BMPs、BMP受体丝氨酸/苏氨酸激酶和BMP信号转导分子（Smads）也被认为与哺乳动物后肾发育有关。似乎特定的BMPs在肾发育的特定方面起着关键作用。本文综述了特定BMPs具体作用的当前知识和证据。