Butler J V, Mulkerrin E C, O'Keeffe S T
Department of Medicine for the Elderly, University College Hospital and Merlin Park Hospital, Galway, Ireland.
Postgrad Med J. 2002 Oct;78(924):596-8. doi: 10.1136/pmj.78.924.596.
Nocturnal leg cramps are common in older people. Such cramps are associated with many common diseases and medications. Physiological methods may be useful for preventing cramps in some people, but there have been no controlled trials of these approaches. Quinine is moderately effective in preventing nocturnal leg cramps. However, there are concerns about the risk/benefit ratio with this drug. In patients with severe symptoms, a trial of 4-6 weeks' treatment with quinine is probably still justified, but the efficacy of treatment should be monitored, for example using a sleep and cramp diary.
夜间腿部抽筋在老年人中很常见。这种抽筋与许多常见疾病和药物有关。生理方法可能对某些人预防抽筋有用,但尚未对这些方法进行对照试验。奎宁在预防夜间腿部抽筋方面有一定效果。然而,人们担心这种药物的风险/效益比。对于症状严重的患者,进行为期4至6周的奎宁治疗试验可能仍有必要,但应监测治疗效果,例如使用睡眠和抽筋日记。