Kharfi Monia, Chtourou Olfa, Kamoun Fatma, Mokhtar Insaf, Fazaa Becima, Ben Salem Moez, Kamoun Mohamed Ridha
Service de dermatologie, Hôpital Charles Nicolle, 1006 Tunis.
Tunis Med. 2002 Apr;80(4):214-6.
Various treatment modalities are used to treat warts and this indicates that none is uniformly effective. Cimetidine, an H2-receptor antagonist, has been tried to treat warts because of its immunomodulatory effects. Sixty children with multiple and recalcitrant warts were included in a placebo-controlled, double-blind study. Patients were randomly allocated to treatment groups equally. The groups received cimetidine, 25 to 30 mg/kg daily, or placebo for 2 months. At the end of the therapy, only 10 cimetidine-treated and 9 placebo-treated were examined. Cure rates obtained were 60% in the cimetidie-treated group and 33% in the placebo-treated group. Among our data and the review of the literature, we believe that cimetidine is not appropriate as standard therapy for warts, but it may be an interested therapy for multiple and recalcitrant warts of children.
有多种治疗方式用于治疗疣，这表明没有一种方法是普遍有效的。西咪替丁，一种H2受体拮抗剂，因其免疫调节作用而被尝试用于治疗疣。一项安慰剂对照、双盲研究纳入了60名患有多发性顽固性疣的儿童。患者被随机平均分配到治疗组。这些组分别接受每日25至30毫克/千克的西咪替丁或安慰剂治疗，为期2个月。治疗结束时，仅对10名接受西咪替丁治疗的患者和9名接受安慰剂治疗的患者进行了检查。西咪替丁治疗组的治愈率为60%，安慰剂治疗组为33%。根据我们的数据以及文献综述，我们认为西咪替丁不宜作为疣的标准治疗方法，但它可能是治疗儿童多发性顽固性疣的一种有趣疗法。
