[血凝酶在腹部手术中的应用及其对血凝的影响]

[Hemocoagulase in abdominal operation and its effect on hemoagglutination].

作者信息

Zhu Mingwei, Cao Jinduo, Jia Zhengeng, Duan Zhiquan, Liu Guojin, Wei Junmin, Long Haikong

机构信息

Department of General Surgery, Beijing Hospital, Beijing 100730, China.

出版信息

Zhonghua Wai Ke Za Zhi. 2002 Aug;40(8):581-4.

PMID:12417069

Abstract

OBJECTIVE

To evaluate the hemostatic role of hemocoagulase in abdominal operation and its effects on coagulation.

METHODS

180 patients receiving abdominal operation were studied prospectively by randomized, double-blind controlled and multicenter design. They were divided into Hemocoagulase group (60 patients), lizhixue group (60), and manitol hexanitrate group (60). The groups were, observed in terms of the effects on hemostatic time, hemorrhagic volume, hemorrhagic volume per square unit, and body coagulation (BT, CT, PT, APTT and PLT) parameters.

RESULTS

The groups received different drugs. The average hemostatic time in the hemocoagulase group was 121.6 s, hemorrhagic volume was 9.6 g, and hemorrhagic volume per square unit was 0.2 g. The similar results were observed in the lizhixue group (P > 0.05), but they were significantly different (P < 0.05) from those of the manitol hexanitrate group (159.2 s, 12.49 g, 0.3 g). In the hemocoagulase and lizhixue groups hemorrhagic and hemoagglution time decreased 30 minutes and 1 day after operation. This finding was significantly differenct from that in the manitol hexanitrate group (P < 0.05).

CONCLUSION

Hemocoagulase plays a good hemostatic role in the hemorrhagic capillary at abdominal incision.

摘要

目的

评估血凝酶在腹部手术中的止血作用及其对凝血的影响。

方法

采用前瞻性、随机、双盲对照、多中心设计，对180例接受腹部手术的患者进行研究。将他们分为血凝酶组（60例）、立止血组（60例）和硝酸甘露醇组（60例）。观察各组对止血时间、出血量、单位面积出血量及机体凝血（BT、CT、PT、APTT和PLT）参数的影响。

结果

各组接受不同药物治疗。血凝酶组平均止血时间为121.6秒，出血量为9.6克，单位面积出血量为0.2克。立止血组结果与之相似（P>0.05），但与硝酸甘露醇组（159.2秒，12.49克，0.3克）有显著差异（P<0.05）。血凝酶组和立止血组术后30分钟和1天时出血及凝血时间缩短。这一结果与硝酸甘露醇组有显著差异（P<0.05）。