[套细胞淋巴瘤的临床病理特征及细胞周期蛋白D1在诊断中的意义]

[Clinicopathologic features of mantle cell lymphoma and the significance of cyclin D1 in diagnosis].

作者信息

He Xiaojin, Li Gandi, Liu Weiping, Lin Yousheng, Li Fenyuan, Liao Dianying

机构信息

Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China.

出版信息

Zhonghua Bing Li Xue Za Zhi. 2002 Aug;31(4):300-4.

PMID:12417084

Abstract

OBJECTIVE

To investigate the clinicopathologic features of mantle cell lymphoma (MCL) and the significance of immunostaining for cyclin D1 in diagnosis.

METHODS

Clinicopathologic observation and immunohistochemical staining for CD20, CD45RO, cyclin D1, bcl-2, Ki-67, CD5 for 8 cases of mantle cell lymphoma were performed.

RESULTS

The 8 cases of mantle cell lymphoma consisted of 6 males and 2 females, aged from 43 to 78 years (mean 57 years). Histopathologically, MCL demonstrated architectural destruction by a vaguely nodular monomorphic lymphoid proliferation with vaguely nodular, diffuse or mantle zone growth patterns. Analogous to centrocytes, the lymphoma cells with slightly to markedly irregular nuclear contours showed moderately dispersed chromatin and a low mitotic figure. Three cases were transformed into highly aggressive blastoid variants. The tumor cells were positive for CD20, CD5, bcl-2 and cyclinD1 in all 8 cases and negative for CD45RO.

CONCLUSIONS

The clinicopathological features and special immunophenotypes were present in mantle cell lymphoma. This tumor can be differentiated from other small B-cell lymphomas on the basis of histopathologic features and positive cyclin D1 immunophenotype. The blastoid variant should also be differentiated from other variants.

摘要

目的

探讨套细胞淋巴瘤（MCL）的临床病理特征及细胞周期蛋白D1免疫染色在诊断中的意义。

方法

对8例套细胞淋巴瘤进行临床病理观察及CD20、CD45RO、细胞周期蛋白D1、bcl-2、Ki-67、CD5的免疫组化染色。

结果

8例套细胞淋巴瘤中男性6例，女性2例，年龄43～78岁（平均57岁）。组织病理学上，MCL表现为结构破坏，呈模糊结节状单形性淋巴细胞增殖，有模糊结节状、弥漫性或套区生长模式。与中心细胞类似，淋巴瘤细胞的核轮廓轻度至明显不规则，染色质呈中度分散，有丝分裂象少。3例转化为高度侵袭性的母细胞样变异型。8例肿瘤细胞CD20、CD5、bcl-2和细胞周期蛋白D1均阳性，CD45RO阴性。