Peerlings Camiel C L, Hanssen Hans H L, Bevers Raymond T J, Boelen Erik J H, Stelt Bram J, Korthagen Eva J M, Koole Leo H
Center for Biomaterials Research, University of Maastricht, P O Box 616, 6200 MD Maastricht, Netherlands.
J Biomed Mater Res. 2002;63(6):692-8. doi: 10.1002/jbm.10381.
Thin metallic wires with an adherent hydrophilic/ lubricious polymeric coating were manufactured in a new extrusion-like procedure. This procedure is part of a novel and efficient way of assembling lubricious guide wires for intravascular interventions, such as percutaneous transluminal angioplasty. It is reported that heparin can readily be incorporated in the hydrophilic coating. A set of heparin-containing guidewire models was made and studied in detail. This showed that (i). immersion of the guide-wire models in an aqueous environment leads to release of heparin from their surface; (ii). the presence of heparin in the coating does not impede the lubricity of the coils; (iii). addition of stearic acid in the coating, next to heparin, does not influence the lubricity of the guide-wire models. Two different charges of heparin (designated heparin-low and heparin-high) were incorporated in the coating. It is discussed that release of heparin from the surface of medical devices (e.g. guide wires and catheters) is much more effective than systemic heparinization, basically because dissolved heparin molecules have a much larger probability of simply passing a medical device's surface (axial convection) rather than contacting it (radial diffusion).
带有附着的亲水性/润滑性聚合物涂层的细金属丝是通过一种类似挤压的新方法制造的。该方法是组装用于血管内介入（如经皮腔内血管成形术）的润滑导丝的新颖且高效方法的一部分。据报道，肝素可容易地掺入亲水性涂层中。制作了一组含肝素的导丝模型并进行了详细研究。结果表明：（i）将导丝模型浸入水性环境会导致肝素从其表面释放；（ii）涂层中肝素的存在不会妨碍线圈的润滑性；（iii）在涂层中除肝素外添加硬脂酸不会影响导丝模型的润滑性。两种不同剂量的肝素（分别称为低肝素和高肝素）被掺入涂层中。讨论指出，肝素从医疗设备（如导丝和导管）表面释放比全身肝素化更有效，主要是因为溶解的肝素分子更有可能简单地通过医疗设备表面（轴向对流）而不是与它接触（径向扩散）。
