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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Dixit V P, Lohiya N K, Arya M, Agrawal M

Acta Biol Med Ger. 1975;34(11-12):1851-6.

Chronic administration of alpha-chlorohydrin (8 mg/kg body wt for 30 days) caused lesions in the testis of dog. The changes in the germ cells were degenerative. The seminiferous tubule and Leydig cell nuclear diameter were reduced. 2. Epididymal cell height was greatly reduced and the stereocilia had disappeared completely. The lumen was devoid of spermatozoa. 3. Alpha-chlorohydrin administration inhibited the RNA and sialic acid contents in the testes and epididymides of dog. Total cholesterol and lipids/g of testes were increased significantly after alpha-chlorohydrin administration. 4. These effects were reversible. Repopulation of testis tubules occurred following a period of 100 days recovery in dog. Numerous spermatogonia and sperm develop and traverse the epididymides. The RNA, sialic acid, cholesterol and total lipids of testes and epididymides returned to subnormal levels. 5. The possibility of using alpha-chlorohydrin as male contraception is indicated.

长期给予α-氯醇（8毫克/千克体重，持续30天）会导致犬睾丸出现病变。生殖细胞发生退行性变化。生精小管和莱迪希细胞核直径减小。2. 附睾细胞高度大幅降低，静纤毛完全消失。管腔内没有精子。3. 给予α-氯醇会抑制犬睾丸和附睾中的RNA及唾液酸含量。给予α-氯醇后，睾丸中每克组织的总胆固醇和脂质显著增加。4. 这些影响是可逆的。犬经过100天的恢复后，睾丸小管重新出现细胞增殖。大量精原细胞和精子发育并通过附睾。睾丸和附睾的RNA、唾液酸、胆固醇及总脂质恢复到低于正常水平。5. 这表明了使用α-氯醇作为男性避孕方法的可能性。

Dixit V P, Lohiya N K, Arya M, Agrawal M

Acta Biol Med Ger. 1975;34(11-12):1851-6.

Chronic administration of alpha-chlorohydrin (8 mg/kg body wt for 30 days) caused lesions in the testis of dog. The changes in the germ cells were degenerative. The seminiferous tubule and Leydig cell nuclear diameter were reduced. 2. Epididymal cell height was greatly reduced and the stereocilia had disappeared completely. The lumen was devoid of spermatozoa. 3. Alpha-chlorohydrin administration inhibited the RNA and sialic acid contents in the testes and epididymides of dog. Total cholesterol and lipids/g of testes were increased significantly after alpha-chlorohydrin administration. 4. These effects were reversible. Repopulation of testis tubules occurred following a period of 100 days recovery in dog. Numerous spermatogonia and sperm develop and traverse the epididymides. The RNA, sialic acid, cholesterol and total lipids of testes and epididymides returned to subnormal levels. 5. The possibility of using alpha-chlorohydrin as male contraception is indicated.

长期给予α-氯醇（8毫克/千克体重，持续30天）会导致犬睾丸出现病变。生殖细胞发生退行性变化。生精小管和莱迪希细胞核直径减小。2. 附睾细胞高度大幅降低，静纤毛完全消失。管腔内没有精子。3. 给予α-氯醇会抑制犬睾丸和附睾中的RNA及唾液酸含量。给予α-氯醇后，睾丸中每克组织的总胆固醇和脂质显著增加。4. 这些影响是可逆的。犬经过100天的恢复后，睾丸小管重新出现细胞增殖。大量精原细胞和精子发育并通过附睾。睾丸和附睾的RNA、唾液酸、胆固醇及总脂质恢复到低于正常水平。5. 这表明了使用α-氯醇作为男性避孕方法的可能性。