羟基脲治疗的Eβ地中海贫血中超氧化物歧化酶的活性
The activity of superoxide dismutase in hydroxyurea-treated E beta thalassemia.
作者信息
Ajanta H, Chakraborty Sheela, Madhusnata De, Bhattacharya D K, Manisha De
机构信息
Thalassaemia Counselling Department, Vivekananda Institute of Medical Science, Ramakrishna Mission Seva Pratisthan, Calcutta, India.
出版信息
J Assoc Physicians India. 2002 Aug;50:1034-5.
AIM
To study the activity of superoxide dismutase (SOD) and the level of fetal hemoglobin (HbF) in hydroxyurea (HU)-treated E beta thalassaemia.
METHODS
We have measured SOD level, HbF, mean corpuscular volume (MCV), packed cell volume (PCV) and hemoglobin (Hb) of E beta thalassaemia treated with HU (dose 30 mg/kg/day) for consecutive 90 days.
RESULT
The increase of HbF synthesis without increase of Hb was observed in HU-treated patients.
CONCLUSION
The decreased SOD level in long term and low dose of HU therapy in E beta thalassaemia may have some role to inhibit superoxide radical of erythrocyte. HU may act as inhibitor for oxidative damage of red cell in E beta thalassaemia.
目的
研究羟基脲（HU）治疗Eβ地中海贫血时超氧化物歧化酶（SOD）的活性及胎儿血红蛋白（HbF）水平。
方法
我们测量了连续90天接受HU（剂量30mg/kg/天）治疗的Eβ地中海贫血患者的SOD水平、HbF、平均红细胞体积（MCV）、红细胞压积（PCV）和血红蛋白（Hb）。
结果
在接受HU治疗的患者中观察到HbF合成增加而Hb未增加。
结论
长期低剂量HU治疗Eβ地中海贫血时SOD水平降低可能在抑制红细胞超氧自由基方面发挥一定作用。HU可能作为Eβ地中海贫血中红细胞氧化损伤的抑制剂。
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