Kawai Yohko, Watanabe Mineo, Matsuura Motohiro, Nishijima Masahiro, Kawahara Kazuyoshi
Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 1-23-1, Toyama-cho, Shinjuku-ku, Tokyo 162-8640, Japan.
FEMS Immunol Med Microbiol. 2002 Nov 15;34(3):173-9. doi: 10.1111/j.1574-695X.2002.tb00621.x.
The partially degraded lipopolysaccharide of Burkholderia cepacia (LPSdegr) and the ornithine-containing lipids were purified from some bacteria. The substances were developed as complex lipid adjuvants, because they have weak toxicity and are able to activate the immune systems of the living body. After various toxoid antigens such as pertussis toxoid, diphtheria toxoid and tetanus toxoid were mixed with the complex lipid adjuvants, the mixtures were administered to mice subcutaneously. Antitoxoid IgG antibody titers in the serum were measured several times over 3 months. The efficacy of the LPSdegr as adjuvant was almost as high as that of the ornithine-containing lipids, and it was almost equal to that of the aluminum hydroxide adjuvant (Alum), which is generally used as a vaccine adjuvant.
