Bougeard Renaud, Fischer Catherine
Functional Neurology and Epileptology Unit, University Neurological Hospital, Lyon, France.
Epileptic Disord. 2002 Sep;4 Suppl 1:S29-32.
Experiments in animals have shown that the temporal pole and the amygdala are involved in auditory processing. Comparable data are scarce in humans. It is only known that after temporal lobectomy, hearing may be impaired and dichotic listening scores reduced on the ear contralateral to the operated temporal lobe. Middle-latency auditory evoked potentials (MLAEPs) and late auditory evoked potentials (LAEPs) have been recorded in 14 patients before and after temporal lobectomy for the treatment of drug-resistant temporal lobe epilepsy. The Na and Pa components of MLAEPs were significantly delayed and the Pa component amplitude reduced before and after surgery as compared to a group of 21 healthy subjects. Data in pre- and postoperative period were not statistically different. N100 and P200 component of LAEPs were similarly altered. It is concluded that in humans the amygdala and probably the temporal pole may be involved in the process of auditory activation-inhibition. The possible role of auditory processing impairment in cognitive deficits in TLE patients can also be questioned.
动物实验表明，颞极和杏仁核参与听觉处理。在人类中，类似的数据很少。仅已知颞叶切除术后，听力可能受损，患侧颞叶对侧耳朵的双耳分听分数降低。对14例因药物难治性颞叶癫痫接受颞叶切除术的患者，在术前和术后记录了中潜伏期听觉诱发电位（MLAEP）和晚潜伏期听觉诱发电位（LAEP）。与21名健康受试者组成的对照组相比，MLAEP的Na和Pa成分在手术前后均显著延迟，且Pa成分波幅降低。术前和术后的数据无统计学差异。LAEP的N100和P200成分也有类似改变。结论是，在人类中，杏仁核以及可能的颞极可能参与听觉激活-抑制过程。颞叶癫痫患者听觉处理障碍在认知缺陷中的可能作用也值得质疑。
