分光光度法测定磺胺醋酰
Spectrophotometric determination of sulphacetamide.
作者信息
Girdhar R, Jain V K, Menon S K, Agrawal Y K
机构信息
Pharmacy Department, Faculty of Technology, M.S. University of Baroda, India.
出版信息
Boll Chim Farm. 2002 Jul-Aug;141(4):311-4.
A new rapid selective spectrophotometric method for the determination of sulphacetamide is described. The drug forms a orange-yellow colored complex with Cerium(IV) in sulfuric acid media which is extracted into ethyl acetate. The complex exhibits a maximum absorbance at 440 nm with a molar absorptivity of 3 x 10(2) 1 mol-1 cm-1. The system obeys Beer's law in the concentration range of 0.07-1.1 mg of sulphacetamide. The various parameters for the optimum extraction conditions are discussed. The method is applied to the determination of sulphacetamide in dosage forms.
本文描述了一种测定磺胺醋酰的快速选择性分光光度法。该药物在硫酸介质中与铈（IV）形成橙黄色络合物，可被萃取到乙酸乙酯中。该络合物在440nm处有最大吸收，摩尔吸光系数为3×10²L·mol⁻¹·cm⁻¹。该体系在0.07 - 1.1mg磺胺醋酰浓度范围内符合比尔定律。讨论了最佳萃取条件的各种参数。该方法应用于剂型中磺胺醋酰的测定。
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