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[用于切除恶性支气管肿瘤的支气管成形手术]

[Bronchoplastic procedures for the resection of malignant bronchial neoplasms].

作者信息

Hollaus P H, Wurnig P N, Pridun N S

机构信息

Thoraxchirurgische Abteilung, Otto Wagner Krankenhaus, Wien, Osterreich,Germany.

出版信息

Chirurg. 2002 Nov;73(11):1115-22. doi: 10.1007/s00104-002-0520-7.

Abstract

INTRODUCTION

Bronchoplastic procedures have become established in the treatment of bronchial malignancies. We report our results on 108 operations performed between 1994 and 2001.

PATIENTS AND METHODS

Bronchial reconstruction techniques (wedge resection, end-to-end-anastomosis, y-sleeve), comorbidity (cardiovascular, respiratory, pulmonary, neoadjuvant chemotherapy, alcoholism), postoperative complications (septic/aseptic, light/severe), histology, tnm-stage and postoperative follow up (days) were recorded prospectively.

RESULTS

The bronchial tree was reconstructed with an end to end anastomosis in 75 cases (69.4%), a y-sleeve in 17 (15.7%) and a wedge resection in 16 (14.8%). In 11 patients (10.2%), an additional angioplasty of the pulmonary artery was performed. The comorbidity rate was 89.8%. A total of 52 patients (49.1%) presented with one or more cardiovascular risk factors and 84 patients (77.8%) with one or more respiratory risk factors. The overall postoperative morbidity was 26.8% and the mortality 5.5%. Aseptic complications were observed in 12 cases (11.1%) with a mortality of 25% while septic complications occurred in 17 patients (15.7%) with a mortality of 17%. Anastomotic fistulas occurred in three patients (2.8%) and pneumonia in 11 (10.2%). Stage I was found in 46 patients (42.6%), 29 (26.8%) had stage II, 21 (19.5%) stage IIIA, five (4.6%) stage IIIB and two had stage IV (1.8%). The follow up period ranged from 64 to 2,654 days (mean 756.42+/-643.46, median 575.0). Seven patients (6.5%) died with no evidence of disease. After 2 years, 65% of all patients were alive, after five years this had dropped to 50%.

CONCLUSION

Bronchoplastic procedures are a safe method for the treatment of bronchial malignancies, even in cases with high comorbidity, and should be performed whenever possible.

摘要

引言

支气管成形手术已成为治疗支气管恶性肿瘤的常用方法。我们报告了1994年至2001年间实施的108例手术的结果。

患者与方法

前瞻性记录支气管重建技术(楔形切除术、端端吻合术、Y形袖状切除术)、合并症(心血管、呼吸、肺部、新辅助化疗、酗酒)、术后并发症(感染性/非感染性、轻度/重度)、组织学、TNM分期及术后随访时间(天数)。

结果

75例(69.4%)采用端端吻合术重建支气管树,17例(15.7%)采用Y形袖状切除术,16例(14.8%)采用楔形切除术。11例患者(10.2%)还进行了肺动脉血管成形术。合并症发生率为89.8%。共有52例患者(49.1%)存在一种或多种心血管危险因素,84例患者(77.8%)存在一种或多种呼吸危险因素。术后总体发病率为26.8%,死亡率为5.5%。观察到12例非感染性并发症(11.1%),死亡率为25%;17例患者发生感染性并发症(15.7%),死亡率为17%。3例患者(2.8%)发生吻合口瘘,11例(10.2%)发生肺炎。46例患者(42.6%)为I期,29例(26.8%)为II期,21例(19.5%)为IIIA期,5例(4.6%)为IIIB期,2例为IV期(1.8%)。随访期为64至2654天(平均756.42±643.46,中位数575.0)。7例患者(6.5%)死亡,尸检无疾病证据。2年后,所有患者中有65%存活,5年后降至50%。

结论

支气管成形手术是治疗支气管恶性肿瘤的一种安全方法,即使在合并症严重的情况下也应尽可能实施。

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