Hollaus P H, Wurnig P N, Pridun N S
Thoraxchirurgische Abteilung, Otto Wagner Krankenhaus, Wien, Osterreich,Germany.
Chirurg. 2002 Nov;73(11):1115-22. doi: 10.1007/s00104-002-0520-7.
Bronchoplastic procedures have become established in the treatment of bronchial malignancies. We report our results on 108 operations performed between 1994 and 2001.
Bronchial reconstruction techniques (wedge resection, end-to-end-anastomosis, y-sleeve), comorbidity (cardiovascular, respiratory, pulmonary, neoadjuvant chemotherapy, alcoholism), postoperative complications (septic/aseptic, light/severe), histology, tnm-stage and postoperative follow up (days) were recorded prospectively.
The bronchial tree was reconstructed with an end to end anastomosis in 75 cases (69.4%), a y-sleeve in 17 (15.7%) and a wedge resection in 16 (14.8%). In 11 patients (10.2%), an additional angioplasty of the pulmonary artery was performed. The comorbidity rate was 89.8%. A total of 52 patients (49.1%) presented with one or more cardiovascular risk factors and 84 patients (77.8%) with one or more respiratory risk factors. The overall postoperative morbidity was 26.8% and the mortality 5.5%. Aseptic complications were observed in 12 cases (11.1%) with a mortality of 25% while septic complications occurred in 17 patients (15.7%) with a mortality of 17%. Anastomotic fistulas occurred in three patients (2.8%) and pneumonia in 11 (10.2%). Stage I was found in 46 patients (42.6%), 29 (26.8%) had stage II, 21 (19.5%) stage IIIA, five (4.6%) stage IIIB and two had stage IV (1.8%). The follow up period ranged from 64 to 2,654 days (mean 756.42+/-643.46, median 575.0). Seven patients (6.5%) died with no evidence of disease. After 2 years, 65% of all patients were alive, after five years this had dropped to 50%.
Bronchoplastic procedures are a safe method for the treatment of bronchial malignancies, even in cases with high comorbidity, and should be performed whenever possible.
支气管成形手术已成为治疗支气管恶性肿瘤的常用方法。我们报告了1994年至2001年间实施的108例手术的结果。
前瞻性记录支气管重建技术(楔形切除术、端端吻合术、Y形袖状切除术)、合并症(心血管、呼吸、肺部、新辅助化疗、酗酒)、术后并发症(感染性/非感染性、轻度/重度)、组织学、TNM分期及术后随访时间(天数)。
75例(69.4%)采用端端吻合术重建支气管树,17例(15.7%)采用Y形袖状切除术,16例(14.8%)采用楔形切除术。11例患者(10.2%)还进行了肺动脉血管成形术。合并症发生率为89.8%。共有52例患者(49.1%)存在一种或多种心血管危险因素,84例患者(77.8%)存在一种或多种呼吸危险因素。术后总体发病率为26.8%,死亡率为5.5%。观察到12例非感染性并发症(11.1%),死亡率为25%;17例患者发生感染性并发症(15.7%),死亡率为17%。3例患者(2.8%)发生吻合口瘘,11例(10.2%)发生肺炎。46例患者(42.6%)为I期,29例(26.8%)为II期,21例(19.5%)为IIIA期,5例(4.6%)为IIIB期,2例为IV期(1.8%)。随访期为64至2654天(平均756.42±643.46,中位数575.0)。7例患者(6.5%)死亡,尸检无疾病证据。2年后,所有患者中有65%存活,5年后降至50%。
支气管成形手术是治疗支气管恶性肿瘤的一种安全方法,即使在合并症严重的情况下也应尽可能实施。