最大直径2厘米及以下肝细胞癌的切除范围
Extent of resection for hepatocellular carcinoma 2 cm or less in greatest diameter.
作者信息
Yamamoto Masakazu, Takasaki Ken, Otsubo Takehito, Saito Akiko, Nakano Masayuki
机构信息
Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, 162-8666, Tokyo, Japan.
出版信息
Am J Surg. 2002 Nov;184(5):437-40. doi: 10.1016/s0002-9610(02)01005-x.
BACKGROUND
The effectiveness of liver segmentectomy or larger resection in patients with hepatocellular carcinoma (HCC) 2 cm or less in greatest diameter has not been clarified.
METHODS
From 1985 to 1994, 125 patients with solitary HCC 2 cm or less in greatest diameter underwent curative hepatectomy (liver segmentectomy or larger resection, 94; subsegmentectomy, 31). The relationship between clinicopathological findings and surgical outcomes were examined.
RESULTS
The 5- and 10-year survival rates were 68% and 47%, respectively. Univariate and multivariate analysis showed the Child-Pugh class to be a significant prognostic factor. However, liver segmentectomy or larger resection did not have any significant effect on long-term survival.
CONCLUSIONS
Our data suggest that no further improvement of the survival rate can be achieved by liver segmentectomy or larger resection, compared with subsegmentectomy in patients with solitary HCC 2 cm or less in greatest diameter.
背景
对于最大直径2厘米及以下的肝细胞癌（HCC）患者，肝段切除术或更大范围切除术的疗效尚未明确。
方法
1985年至1994年，125例最大直径2厘米及以下的孤立性HCC患者接受了根治性肝切除术（肝段切除术或更大范围切除术94例；亚肝段切除术31例）。研究了临床病理特征与手术结果之间的关系。
结果
5年和10年生存率分别为68%和47%。单因素和多因素分析显示，Child-Pugh分级是一个重要的预后因素。然而，肝段切除术或更大范围切除术对长期生存没有任何显著影响。
结论
我们的数据表明，对于最大直径2厘米及以下的孤立性HCC患者，与亚肝段切除术相比，肝段切除术或更大范围切除术无法进一步提高生存率。
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