Zaki Emad L, Springate James E
Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo and The Children's Hospital, Buffalo, New York 14222, USA.
Pediatr Neurol. 2002 Oct;27(4):318-9. doi: 10.1016/s0887-8994(02)00447-2.
A child with developmental delay and epilepsy developed glucosuria approximately 16 months after starting valproic acid therapy. Laboratory evaluation revealed global defects in proximal tubule function consistent with the De Toni-Debré-Fanconi syndrome. Discontinuation of valproate led to complete recovery 5 months later. Review of previously reported cases indicates that this complication is unique to children and reversible when the medication is discontinued.
一名患有发育迟缓及癫痫的儿童在开始丙戊酸治疗约16个月后出现糖尿。实验室评估显示近端肾小管功能存在全面缺陷，符合德托尼-德布雷-范科尼综合征。停用丙戊酸盐5个月后患儿完全康复。对既往报道病例的回顾表明，这种并发症仅见于儿童，停药后可逆转。
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