Hirakata Yoichi
Department of Laboratory Medicine, Nagasaki University School of Medicine.
Nihon Rinsho. 2002 Nov;60(11):2156-60.
Serratia species, in particular, Serratia marcescens frequently causes bloodstream infections. Recently, several outbreaks of nosocomial bloodstream infections due to S. marcescens have been reported in Japan. Although Serratia is an opportunistic pathogen, the organism can develop endotoxin shock and multiple organ failure because of being gram-negative rod when a number of bacteria invade the bloodstream. Serratia in the intestinal tract can invade bloodstream endogenously in compromised hosts. However, the possible causes of an outbreak are contamination of antiseptics, and consequent contamination of transfusion. To prevent outbreaks of S. marcescens bloodstream infection, management of antiseptics and transfusion in addition to contact precaution should be taken.
沙雷氏菌属,尤其是粘质沙雷氏菌,经常引起血流感染。最近,日本报告了几起因粘质沙雷氏菌导致的医院血流感染暴发事件。尽管沙雷氏菌是一种机会致病菌,但当大量细菌侵入血流时,由于它是革兰氏阴性杆菌,该菌体会引发内毒素休克和多器官功能衰竭。肠道中的沙雷氏菌可在免疫功能低下的宿主中内源性地侵入血流。然而,暴发的可能原因是防腐剂受到污染,进而导致输血污染。为预防粘质沙雷氏菌血流感染的暴发,除接触预防措施外,还应加强对防腐剂和输血的管理。