连接蛋白36形成了对夜间视力至关重要的突触。

Connexin36 forms synapses essential for night vision.

作者信息

Demb Jonathan B, Pugh Edward N

机构信息

Department of Neuroscience, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA.

出版信息

Neuron. 2002 Nov 14;36(4):551-3. doi: 10.1016/s0896-6273(02)01062-0.

DOI:10.1016/s0896-6273(02)01062-0

PMID:12441044

Abstract

Rod signals reach ganglion cells via at least five pathways. A new study in this issue of Neuron shows that all pathways from rods to ON-type ganglion cells require connexin36. This is the first physiological demonstration in mammals that a well-defined neural circuit requires a gap junction as an obligatory transmission step.

摘要

视杆细胞信号通过至少五条通路到达神经节细胞。本期《神经元》杂志上的一项新研究表明，从视杆细胞到ON型神经节细胞的所有通路都需要连接蛋白36。这是哺乳动物中首次在生理层面证明一个明确的神经回路需要间隙连接作为必要的传递步骤。