通过乌吉反应合成手性三羰基铬标记的胸腺嘧啶肽核酸单体。

Synthesis of chiral chromium tricarbonyl labeled thymine PNA monomers via the Ugi reaction.

作者信息

Baldoli Clara, Maiorana Stefano, Licandro Emanuela, Zinzalla Giovanna, Perdicchia Dario

机构信息

CNR Istituto di Scienze e Tecnologie Molecolari e Dipartimento di Chimica Organica e Industriale, University of Milan, Via C. Golgi 19, I-20133 Milano, Italy.

出版信息

Org Lett. 2002 Nov 28;4(24):4341-4. doi: 10.1021/ol026994a.

DOI:10.1021/ol026994a

PMID:12443093

Abstract

[reaction: see text] Ugi condensation was used to synthesize the first examples of chiral racemic Ar.Cr(CO)(3) labeled peptide nucleic acid (PNA) monomers bearing the organometallic moiety linked to the alpha-carbon of the glycine unit.

摘要

[反应：见正文]乌吉缩合反应被用于合成首例手性外消旋的带有与甘氨酸单元α-碳相连的有机金属部分的Ar·Cr(CO)₃标记的肽核酸（PNA）单体。