既往存在的焦虑症能否预测肠易激综合征患者对帕罗西汀的反应？

Does a preexisting anxiety disorder predict response to paroxetine in irritable bowel syndrome?

作者信息

Masand Prakash S, Gupta Sanjay, Schwartz Thomas L, Kaplan David, Virk Subhdeep, Hameed Ahmad, Lockwood Kari

机构信息

Department of Psychiatry, Duke University Medical Center, Durham, NC 27710, USA.

出版信息

Psychosomatics. 2002 Nov-Dec;43(6):451-5. doi: 10.1176/appi.psy.43.6.451.

DOI:10.1176/appi.psy.43.6.451

PMID:12444227

Abstract

Irritable bowel syndrome (IBS) is the most common disorder in patients seen by gastroenterologists. Twenty subjects with IBS diagnosed with the Rome criteria were treated for 12 weeks with 20-40 mg/day of paroxetine (mean dose=31 mg/day). At baseline, 10 patients had a lifetime history of an anxiety disorder, and 10 patients did not have such a history. Both groups had similar improvement in abdominal pain, constipation, diarrhea, incomplete emptying, and bloating/ abdominal distension. Paroxetine was very well tolerated.

摘要

肠易激综合征（IBS）是胃肠病学家诊治患者中最常见的疾病。20名根据罗马标准诊断为IBS的受试者接受了为期12周的治疗，每天服用20 - 40毫克帕罗西汀（平均剂量 = 31毫克/天）。基线时，10名患者有焦虑症终生病史，10名患者无此病史。两组在腹痛、便秘、腹泻、排空不全和腹胀方面均有相似程度的改善。帕罗西汀耐受性良好。