Identification of a new HLA-DRB1 allele, DRB1*0321.

This communication reports the identification of a new HLA-DRB103 allele identified in three members of a Caucasian French family. This new allele has been officially named HLA-DRB10321 by the World Health Organization Nomenclature Committee. The complete exon 2 sequence of DRB10321 is identical to that of DRB10307 except for the first and second nucleotides of codon 37 (TT replacing AA), which lead to the substitution of a tyrosine for a phenylalanine (AAC-->TTC at position 37). The family study showed that this new allele was transmitted into the HLA-A0101/09, -B0801/14, -Cw0701, -DRB10321, -DRB30101, -DQB10503 and -DPB1*0401 haplotype. The complete exon 2 sequence of this new allele has been previously deposited in the EMBL Sequence Database under accession number AF297266.