Best J, Lavender J P, Russell S, Sherwood T
Nephron. 1976;16(3):188-96. doi: 10.1159/000180601.
Ischaemic renal failure in the dog was studied by clamping one renal artery for 2 hr in 18 animals. Total renal blood flow was measured for 3 hr after this and only reduced by about 30%. Fine detail renal angiography showed a normal cortical perfusion pattern. Urine flow rates and creatinine clearances from these kidneys, however, were found to be grossly impaired over this period. Seven days later the angiogram of the oliguric kidney remained normal. Two-hour unilateral renal ischaemia in the dog leads to a form of acute renal failure with a striking disparity between glomerular perfusion and clearance, arguing agains a primary circulatory defect.
通过夹闭18只狗的一侧肾动脉2小时来研究犬缺血性肾衰竭。夹闭后3小时测量总肾血流量，仅减少约30%。精细的肾血管造影显示皮质灌注模式正常。然而，在此期间发现这些肾脏的尿流率和肌酐清除率严重受损。7天后，少尿肾的血管造影仍正常。犬单侧肾缺血2小时会导致一种急性肾衰竭，肾小球灌注与清除之间存在明显差异，这与原发性循环缺陷不符。
