Marchalonis John J, Jensen Ingvill, Schluter Samuel F
University of Arizona, Department of Microbiology and Immunology, College of Medicine, Tucson, AZ 85724, USA.
J Mol Recognit. 2002 Sep-Oct;15(5):260-71. doi: 10.1002/jmr.586.
We have had the pleasure of collaborating with Allen Edmundson for the past 15 years on the structure, binding properties and evolution of immunoglobulins and T cell receptors. Among the most significant contributions of our joint efforts were: (1) the predictive use of structural features of immunoglobulin domains to model the three-dimensional structures of the immunoglobulin domains of human T-cell receptor alpha and beta chains as well as shark light chains and V(H) domains; (2) the finding that normal humans and other vertebrates express autoantibodies against combining site epitopes of their own T cell receptors; (3) the mapping of the peptide autoepitopes recognized in health, autoimmunity and retroviral infection; and (4) the determination that epitope recognition promiscuity is a characteristic property of the combining sites of IgM immunoglobulins ranging from those of sharks to those of humans. We briefly review the salient findings and status of these studies and indicate the future directions that we will pursue in their continuation.
在过去的15年里，我们有幸与艾伦·埃德蒙森合作，研究免疫球蛋白和T细胞受体的结构、结合特性及进化。我们共同努力取得的最重要成果包括：（1）利用免疫球蛋白结构域的结构特征预测人类T细胞受体α和β链以及鲨鱼轻链和V(H)结构域的免疫球蛋白结构域的三维结构；（2）发现正常人类和其他脊椎动物表达针对自身T细胞受体结合位点表位的自身抗体；（3）绘制在健康、自身免疫和逆转录病毒感染中识别的肽自身表位图谱；（4）确定表位识别多特异性是从鲨鱼到人类的IgM免疫球蛋白结合位点的特征属性。我们简要回顾这些研究的主要发现和现状，并指出我们在后续研究中将遵循的未来方向。
