Perales Miguel-Angel, Wolchok Jedd D
Clinical Immunology Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Joan and Sanford I. Weill Medical College of Cornell University, 1275 York Avenue, New York, NY 10021, USA.
Cancer Invest. 2002;20(7-8):1012-26. doi: 10.1081/cnv-120005918.
The identification of antigens on tumor cells has led to significant contributions to the field of immunotherapy. One of the most active areas under investigation in cancer immunotherapy is the development of vaccines against melanoma antigens. Induction of immunity against tumor antigens can follow multiple routes using different mechanisms. Crucial to the development of active immunization and other immunotherapies is the discovery and understanding of the molecular identity of antigens and the mechanisms involved in tumor immunity, as well as escape from immunity. In this review, we will discuss strategies to induce active immunity against melanoma.
肿瘤细胞上抗原的鉴定为免疫治疗领域做出了重大贡献。癌症免疫治疗中最活跃的研究领域之一是针对黑色素瘤抗原的疫苗开发。针对肿瘤抗原的免疫诱导可通过多种途径利用不同机制实现。主动免疫和其他免疫治疗发展的关键在于发现和理解抗原的分子特性、肿瘤免疫所涉及的机制以及免疫逃逸机制。在本综述中，我们将讨论诱导针对黑色素瘤的主动免疫的策略。
