[口服锌剂对摄入镅清除作用的研究]

[Study of the influence of peroral zincacin on the removing of ingested Americium].

作者信息

Zhorova E S, Il'in L A, Ivannikov A T, Popov B A, Parfenova I M

机构信息

State Research Center-Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia.

出版信息

Radiats Biol Radioecol. 2002 Sep-Oct;42(5):520-5.

PMID:12449820

Abstract

Effect of different cincacine doses was studied in rats ingesting americium citrate during 2 weeks. As a result new data showing the possibility and efficacy of per oral cincacine administration at americium intake into digestive tract have been obtained. Dose dependence of cincacine efficacy has been stated for per oral 241Am intake. Preparation administration at a dose of 25 mumol/kg reduces amount of 241Am in skeleton, liver and kidney by 93, 90 and 33%, respectively and is optimum for radionuclide removal from the body and for the prevention of its deposition in organs. Digestive system organs and kidney structure at cincacine administration at a dose of 150 and 300 mumol/kg) to the rats ingesting 241Am have been studied.

摘要

研究了不同剂量新斯的明对摄入柠檬酸镅两周的大鼠的影响。结果获得了新的数据，表明在镅摄入消化道时经口给予新斯的明的可能性和有效性。已表明经口摄入241Am时新斯的明疗效的剂量依赖性。以25 μmol/kg的剂量给药制剂可使骨骼、肝脏和肾脏中的241Am含量分别降低93%、90%和33%，这对于从体内清除放射性核素及其在器官中的沉积预防而言是最佳的。已研究了以150和300 μmol/kg的剂量向摄入241Am的大鼠给予新斯的明时的消化系统器官和肾脏结构。