肿瘤坏死因子-肿瘤坏死因子受体系统

The TNF-TNF receptor system.

作者信息

Hehlgans Thomas, Männel Daniela N

机构信息

Department of Pathology/Tumor Immunology, University of Regensburg, D-93042 Regensburg, Germany.

出版信息

Biol Chem. 2002 Oct;383(10):1581-5. doi: 10.1515/BC.2002.178.

DOI:10.1515/BC.2002.178

PMID:12452434

Abstract

Different forms of tumor necrosis factor (TNF) interact with two specific receptors for TNF (TNFR) on the cell membrane to induce a variety of effects. While sharing structural similarities in their extracellular domains, the two TNFRs differ in their intracellular domain, their signal transduction, and consequently their function. In addition, one of the two TNFRs can be expressed in two differently located isoforms. This makes the TNF-TNFR system very complex. The dual TNF function for either cell death or survival upon interaction of members of the TNF ligand family with members of the TNF receptor family will be discussed.

摘要

不同形式的肿瘤坏死因子（TNF）与细胞膜上两种特定的TNF受体（TNFR）相互作用，从而引发多种效应。虽然这两种TNFR在细胞外结构域具有结构相似性，但它们的细胞内结构域、信号转导以及相应的功能却有所不同。此外，两种TNFR中的一种可以以两种位于不同位置的异构体形式表达。这使得TNF-TNFR系统非常复杂。我们将讨论TNF配体家族成员与TNF受体家族成员相互作用时，TNF在细胞死亡或存活方面的双重功能。