L型钙通道拮抗剂地尔硫䓬对双酚A增强1-甲基-4-苯基吡啶离子在大鼠纹状体中产生羟自由基的保护作用。
Protective effect of diltiazem, a L-type calcium channel antagonist, on bisphenol A-enhanced hydroxyl radical generation by 1-methyl-4-phenylpyridinium ion in rat striatum.
作者信息
Obata Toshio, Kinemuchi Hiroyasu, Aomine Masahiro
机构信息
Department of Pharmacology and Therapeutics, Oita Medical University, 1-1 Idaigaoka, Hasama, Oita 879-5593, Japan.
出版信息
Neurosci Lett. 2002 Dec 16;334(3):211-3. doi: 10.1016/s0304-3940(02)01110-2.
The present study examined whether bisphenol A enhanced 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in rat striatum using microdialysis technique. These elevations were detected by increases in non-enzymatic formation of 2,3-dihydroxybenzoic acid levels. Bisphenol A significantly enhanced MPP+-induced.OH generation. Further, the effect of diltiazem, a L-type Ca2+ channel antagonist, on bisphenol A (10 microM) and MPP+ (5 mM)-induced.OH generation were studied. Ddiltiazem (100 microM) significantly suppressed bisphenol A and MPP+-induced.OH generation. The results indicate bisphenol A augmented *OH generation, and diltiazem may have preventive effect on bisphenol A and MPP+-induced.OH generation.
本研究使用微透析技术检测了双酚A是否会增强1-甲基-4-苯基吡啶离子（MPP⁺）诱导的大鼠纹状体中羟自由基（·OH）的生成。通过2,3-二羟基苯甲酸水平的非酶促形成增加来检测这些升高情况。双酚A显著增强了MPP⁺诱导的·OH生成。此外，还研究了L型钙通道拮抗剂地尔硫䓬对双酚A（10微摩尔）和MPP⁺（5毫摩尔）诱导的·OH生成的影响。地尔硫䓬（100微摩尔）显著抑制了双酚A和MPP⁺诱导的·OH生成。结果表明双酚A增加了·OH的生成，并且地尔硫䓬可能对双酚A和MPP⁺诱导的·OH生成具有预防作用。
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