HLA-DR基因座在不同临床类型斑秃患者中的保护作用。

The protective role of the HLA-DR locus in patients with various clinical types of alopecia areata.

作者信息

Broniarczyk-Dyła Grazyna, Prusińska-Bratoś Magdalena, Dubla-Berner Małgorzata, Arkuszewska Celina, Borowiec Maciej, Kowalski Marek L, Woszczek Grzegorz

机构信息

Department and Clinic of Dermatology and Venereology, Medical University of Lódź.

出版信息

Arch Immunol Ther Exp (Warsz). 2002;50(5):333-6.

PMID:12455867

Abstract

One of the genetic factors associated with the development of alopecia areata (AA) is the HLA locus. The study comprised 52 patients with AA aged 10 to 64 years. The frequences of HLA-DRB alleles in the patients and controls were compared. The control group comprised 152 healthy persons. Familial occurrence of AA was seen in 7 (13.5%) cases. A significantly lower frequency of HLA-DRB103 was observed in patients with AA comparison with the control group. In all patients with AA, alleles HLA-DRB115/*16 occurred more frequently than in the control group, but this was not significant after correction. In the group of patients with more severe forms of alopecia areata (alopecia areata totalis/alopecia areata universalis) there was no significant difference in HLA-DR allele distribution.

摘要

与斑秃（AA）发病相关的遗传因素之一是HLA基因座。该研究纳入了52例年龄在10至64岁之间的斑秃患者。比较了患者和对照组中HLA-DRB等位基因的频率。对照组由152名健康人组成。7例（13.5%）病例出现斑秃家族史。与对照组相比，斑秃患者中HLA-DRB103的频率显著降低。在所有斑秃患者中，HLA-DRB115/*16等位基因的出现频率高于对照组，但校正后差异无统计学意义。在更严重的斑秃形式（全秃/普秃）患者组中，HLA-DR等位基因分布无显著差异。