Suppr超能文献

成人头颈部肉瘤的管理

Management of sarcomas of the head and neck in adults.

作者信息

Pellitteri Phillip K, Ferlito Alfio, Bradley Patrick J, Shaha Ashok R, Rinaldo Alessandra

机构信息

Department of Otolaryngology--Head and Neck Surgery, Geisinger Medical Center, Danville, Pennsylvania, USA.

出版信息

Oral Oncol. 2003 Jan;39(1):2-12. doi: 10.1016/s1368-8375(02)00032-5.

Abstract

Sarcomas account for less than 1% of all malignant neoplasms occurring in the head and neck in adults. These tumors exhibit variable growth and degrees of aggressiveness which are primarily dependent on histologic grade. The pattern of growth demonstrated by sarcomas is generally by local advancement with high-grade tumor exhibiting extensive involvement of adjacent visceral and neurovascular structures. Regional metastasis is uncommon. Etiologic considerations include the tumorigenic effects of prior external beam radiotherapy and the development of second malignancies in the form of sarcomas. The clinical presentation of these neoplasms is variable and dependent on subsite of involvement as well as the aggressiveness of tumor growth. Histologic diagnosis is frequently challenging, often requiring the aid of immunohistochemical staining techniques. Treatment is predominantly surgical, utilizing wide local excision where en-bloc resection is feasible. Radiotherapy, by means of external beam or implant, plays an important adjunctive role in management, especially for tumors where en-bloc resection with margin control is not possible. Chemotherapy regimens are available for soft tissue neoplasms and osteosarcoma and are primarily designed to improve local control. Survival is predicted on the incidence of local recurrence and risk of distant metastasis, both of which are influenced by tumor grade. Low-grade tumors exhibit improved survival over that of less differentiated tumors.

摘要

肉瘤在成人头颈部所有恶性肿瘤中所占比例不到1%。这些肿瘤生长方式各异,侵袭程度不同,主要取决于组织学分级。肉瘤的生长模式通常是局部进展,高级别肿瘤会广泛累及相邻的内脏和神经血管结构。区域转移并不常见。病因学方面的考虑因素包括既往外照射放疗的致瘤作用以及肉瘤形式的第二原发恶性肿瘤的发生。这些肿瘤的临床表现各不相同,取决于受累的亚部位以及肿瘤生长的侵袭性。组织学诊断常常具有挑战性,通常需要免疫组化染色技术的帮助。治疗主要是手术,在可行整块切除的情况下采用广泛局部切除。通过外照射或植入进行的放疗在治疗中起着重要的辅助作用,特别是对于无法进行带切缘控制的整块切除的肿瘤。软组织肿瘤和骨肉瘤有化疗方案,主要目的是改善局部控制。生存情况根据局部复发率和远处转移风险来预测,这两者均受肿瘤分级影响。低级别肿瘤的生存率高于分化程度较低的肿瘤。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验