Smialowicz R J
Immunotoxicology Branch, Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA.
Hum Exp Toxicol. 2002 Sep-Oct;21(9-10):513-9. doi: 10.1191/0960327102ht290oa.
Evidence is presented to demonstrate that the rat is a sensitive rodent species for developmental immunotoxicity testing of chemicals. A battery of immune function assays was performed in adult rats, which were exposed perinatally (i.e., during gestational, lactational, and/or juvenile development) to three different classes of environmental chemicals. The chemicals employed were the following: the organotins di-n-octyltindichloride (DOTC) and tributyltin oxide (TBTO); the polyhalogenated aromatic hydrocarbon 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); and the organochlorine pesticides methoxychlor (MXC) and heptachlor (HEP). Suppression of immune function was observed in adult rats exposed to each of these chemicals during immune system development. The duration of immune function suppression in the rats so exposed ranged from three weeks (i.e., DOTC and MXC) to 19 months (i.e., TCDD) after the last exposure to the chemical.
有证据表明，大鼠是用于化学物质发育免疫毒性测试的敏感啮齿动物物种。对成年大鼠进行了一系列免疫功能测定，这些大鼠在围产期（即妊娠、哺乳和/或幼年发育期间）接触了三类不同的环境化学物质。所使用的化学物质如下：有机锡二正辛基二氯化锡（DOTC）和三丁基氧化锡（TBTO）；多卤代芳烃2,3,7,8-四氯二苯并对二恶英（TCDD）；以及有机氯农药甲氧滴滴涕（MXC）和七氯（HEP）。在免疫系统发育期间接触这些化学物质的成年大鼠中观察到免疫功能受到抑制。这些大鼠接触化学物质后免疫功能抑制的持续时间从最后一次接触化学物质后的三周（即DOTC和MXC）到19个月（即TCDD）不等。
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