Bardeesy Nabeel, DePinho Ronald A
Department of Adult Oncology, Dana-Farber Cancer Institute and Departments of Medicine and Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nat Rev Cancer. 2002 Dec;2(12):897-909. doi: 10.1038/nrc949.
Pancreatic ductal adenocarcinoma is an aggressive and devastating disease, which is characterized by invasiveness, rapid progression and profound resistance to treatment. Advances in pathological classification and cancer genetics have improved our descriptive understanding of this disease; however, important aspects of pancreatic cancer biology remain poorly understood. What is the pathogenic role of specific gene mutations? What is the cell of origin? And how does the stroma contribute to tumorigenesis? A better understanding of pancreatic cancer biology should lead the way to more effective treatments.
胰腺导管腺癌是一种侵袭性强且极具破坏性的疾病，其特征为具有侵袭性、进展迅速且对治疗具有高度抗性。病理分类和癌症遗传学的进展增进了我们对这种疾病的描述性认识；然而，胰腺癌生物学的重要方面仍了解甚少。特定基因突变的致病作用是什么？起源细胞是什么？以及基质如何促进肿瘤发生？对胰腺癌生物学的更好理解应能引领出更有效的治疗方法。
