Sairam K, Kulinskaya E, McNicholas T A, Boustead G B, Hanbury D C
Lister Hospital Stevenage, and Health Research Support Unit (HRDSU), Hatfiel, Herts, UK.
BJU Int. 2002 Dec;90(9):836-9. doi: 10.1046/j.1464-410x.2002.03040.x.
To assess the possible relationship between erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) in men, and whether treatment of their ED with sildenafil influences their LUTS.
In all, 112 men with ED attending the andrology outpatient clinic were offered oral sildenafil and reviewed 1 and 3 months after treatment. They completed the International Index of Erectile Function and the International Prostate Symptom Score (IPSS) questionnaires at baseline and each review. Scores were designated to indicate the visit number and differences between the visits calculated.
A third of the men had an initial IPSS of > 7; there was no relationship between baseline urinary and sexual function scores. After treatment with sildenafil, the urinary scores at 3 months correlated strongly with the sexual function scores. There was a significant inverse relationship between the baseline IPSS and sexual function scores after treatment. The overall trend in the IPSS was towards improvement after treatment with sildenafil.
In men with ED there is no relationship between sexual function scores and urinary symptom scores before treating ED. Treatment with sildenafil appears to improve urinary symptom scores. A lower IPSS at baseline appears to predict a better response to ED therapy with sildenafil.
评估男性勃起功能障碍（ED）与下尿路症状（LUTS）之间的可能关系，以及使用西地那非治疗ED是否会影响其LUTS。
总共112名就诊于男科门诊的ED男性患者接受了口服西地那非治疗，并在治疗后1个月和3个月进行复查。他们在基线期及每次复查时完成国际勃起功能指数和国际前列腺症状评分（IPSS）问卷。对评分进行标注以表明就诊次数，并计算就诊之间的差异。
三分之一的男性患者初始IPSS>7；基线期排尿功能评分与性功能评分之间无关联。使用西地那非治疗后，3个月时的排尿功能评分与性功能评分密切相关。治疗后，基线期IPSS与性功能评分之间存在显著的负相关关系。使用西地那非治疗后，IPSS的总体趋势是改善。
在患有ED的男性中，治疗ED之前性功能评分与排尿症状评分之间无关联。使用西地那非治疗似乎可改善排尿症状评分。基线期较低的IPSS似乎预示着对西地那非治疗ED的反应更好。
