Sakamoto Kazuhiko, Ohata Mitsuru, Hashimoto Kenichi, Uetake Sinichiro, Kawashima Osamu, Takeda Kunihiko, Nakajima Hisato, Yamauchi Masayoshi, Toda Gotaro, Takao Hiroyuki, Shingai Noritoshi
Division of Gastroenterology and Hepatology, Department of Internal Medicine, Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, Japan.
Nihon Arukoru Yakubutsu Igakkai Zasshi. 2002 Oct;37(5):505-12.
Two cases of alcoholics associated with rhabdomyolysis and acute renal failure were reported. Case 1 was a 67-year-old male who had complained of general fatigue and generalized muscle pain. He had drunken and slept outdoor in winter until he was found. Laboratory data on admission showed remarkable elevation of muscle enzymes (AST, LDH, CPK) and serum levels of myoglobin, BUN, and Cr. He was treated with hemodialysis because of acute renal failure caused by rhabdomyolysis and recovered from renal failure. Case 2 was a 50-year-old male who had been unconscious and suffered from muscle weakness. He had drunken and slept in the bed for several days without eating any food until he was found by his sister. Laboratory data on admission showed remarkable elevation of muscle enzymes and serum levels of myoglobin, BUN, and Cr. It also showed hypoglycemia and hyponatremia. He developed into acute renal failure caused by rhabdomyolysis, but had a good clinical course without hemodialysis. The rhabdomyolysis of case 1 might have been caused by alcohol and sleeping outdoor in winter. That of case 2 might have been caused by alcohol and pressure necrosis due to immobility for several days in his bed.
报告了两例与横纹肌溶解症和急性肾衰竭相关的酗酒病例。病例1是一名67岁男性，主诉全身乏力和全身肌肉疼痛。他在冬季醉酒后睡在户外，直至被发现。入院时的实验室检查数据显示肌肉酶（AST、LDH、CPK）以及血清肌红蛋白、尿素氮和肌酐水平显著升高。由于横纹肌溶解症导致急性肾衰竭，他接受了血液透析治疗，并从肾衰竭中康复。病例2是一名50岁男性，曾昏迷且伴有肌肉无力。他醉酒后在床上躺了几天未进食，直至被其姐姐发现。入院时的实验室检查数据显示肌肉酶以及血清肌红蛋白、尿素氮和肌酐水平显著升高。还显示有低血糖和低钠血症。他因横纹肌溶解症发展为急性肾衰竭，但未进行血液透析，临床过程良好。病例1的横纹肌溶解症可能是由酒精和冬季户外睡眠所致。病例2的横纹肌溶解症可能是由酒精以及在床上数天不动导致的压迫性坏死所致。
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