Takken Tim, Hemel Arlette, van der Net Janjaap, Helders Paul J M
Department of Pediatric Physical Therapy, University Hospital for Children and Youth Het Wilhelmina Kinderziekenhuis, Utrecht, The Netherlands.
J Rheumatol. 2002 Dec;29(12):2643-7.
To determine whether children with juvenile idiopathic arthritis (JIA) have lower physical fitness compared to healthy children, and to determine the clinical relevance of this impairment.
A systematic literature search was performed using MEDLINE, CINAHL, EMBASE and SPORTDiscus. The appropriate titles were identified and the data were extracted from these publications. The maximal oxygen consumption (VO2peak; in ml.kg-1.min-1) during a maximal exercise test until volitional exhaustion was used as the main outcome for this review.
Nine studies were identified in the literature. Data from 5 studies (144 patients) were pooled in a metaanalysis. The VO2peak of the patients with JIA was 21.8% (95% CI 13.7, 29.9) lower than that of healthy children (p < 0.0001).
The results of the metaanalysis suggest that children with JIA have moderate to heavy impairment in physical fitness as represented by maximal oxygen consumption compared to healthy children.
确定与健康儿童相比，幼年特发性关节炎（JIA）患儿的体能是否较低，并确定这种损害的临床相关性。
使用MEDLINE、CINAHL、EMBASE和SPORTDiscus进行系统的文献检索。识别出合适的标题，并从这些出版物中提取数据。将最大运动试验直至自愿疲劳时的最大耗氧量（VO2peak；单位为ml.kg-1.min-1）用作本次综述的主要结果。
文献中识别出9项研究。5项研究（144例患者）的数据被纳入荟萃分析。JIA患儿的VO2peak比健康儿童低21.8%（95%CI 13.7，29.9）（p<0.0001）。
荟萃分析结果表明，与健康儿童相比，JIA患儿在以最大耗氧量表示的体能方面存在中度至重度损害。
