Watanabe Takeshi, Yamamoto Rie, Maeda Akifumi, Nakagawa Takayuki, Minami Masabumi, Satoh Masamichi
Department of Molecular Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto 606-8501, Japan.
Brain Res. 2002 Dec 27;958(2):423-8. doi: 10.1016/s0006-8993(02)03468-6.
We examined the effects of discrete, bilateral excitotoxic lesions of the central or basolateral nucleus of the amygdala on naloxone-precipitated withdrawal-induced conditioned place aversion in morphine-dependent rats. Lesions of the central nucleus significantly attenuated the conditioned place aversion, while lesions of the basolateral nucleus had little effect. These results suggest that the central nucleus of the amygdala, rather than the basolateral nucleus, plays a crucial role in the negative affective component of morphine abstinence.
我们研究了杏仁核中央核或基底外侧核的离散性双侧兴奋性毒性损伤对吗啡依赖大鼠中纳洛酮诱发的戒断诱导条件性位置厌恶的影响。中央核损伤显著减弱了条件性位置厌恶，而基底外侧核损伤几乎没有影响。这些结果表明，在吗啡戒断的负面情感成分中，起关键作用的是杏仁核中央核，而非基底外侧核。
